Synonym: Serotransferrin, Siderophilin
Species: Human
Protein Accession: P02787
Purity: Greater than 95%
Endotoxin Level: Less than 1 EU/μg
Biological Activity: Not specified
Expression System: Human cell line
Fusion Tag: None
Predicted Molecular Mass: Approximately 77 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS
Reconstitution: Reconstitute in sterile distilled water or aqueous buffer
containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml
Storage & Stability: Store at -20°C upon receipt, stable for up to 6 months at
-20°C. Avoid multiple freeze-thaw cycles.
FAQ
What are the primary benefits of including transferrin in animal feed?
Transferrin, a
globular protein, plays a critical role in the transport and regulation of iron within
the body. Incorporating transferrin into animal feed offers multiple benefits. Firstly,
it significantly enhances the bioavailability of iron, an essential nutrient for growth
and metabolic functions. This leads to improved hemoglobin levels and overall better
health in livestock. Secondly, transferrin acts as an antimicrobial agent by
sequestering free iron, which many pathogens require for their growth. This reduces the
need for antibiotics, supporting a more natural and sustainable approach to livestock
farming. Additionally, transferrin helps mitigate anemia and related disorders, thereby
improving the overall vitality and productivity of the animals. By boosting the immune
system, it also reduces mortality rates and improves feed efficiency, translating into
better economic returns for farmers.
How does transferrin improve iron absorption
in livestock?
Transferrin improves iron absorption by binding to free iron in the
gastrointestinal tract and transporting it directly into the bloodstream. This complex
avoids the formation of insoluble iron compounds that can occur in the digestive system,
thus enhancing the efficiency of iron uptake. Moreover, transferrin receptors are
expressed on the surface of cells in various tissues, including the liver, spleen, and
bone marrow, which are the primary sites of iron utilization and storage. When
transferrin binds to these receptors, iron is efficiently delivered where it is most
needed. This targeted approach not only optimizes iron absorption but also minimizes
wastage and potential toxicity associated with excess free iron in the body.
What
effects does transferrin have on the health and growth of livestock?
Transferrin can
profoundly impact the health and growth of livestock. By ensuring efficient iron
transport and reducing iron deficiency, animals experience improved hemoglobin levels
and better oxygen transport throughout the body. This contributes to increased energy
levels, better weight gain, and higher overall productivity. Moreover, by sequestering
iron and restricting its availability to pathogens, transferrin acts as a natural
defense mechanism, reducing the incidence of infections and improving the overall immune
response. Healthier animals mean a lower need for medical interventions and a decrease
in livestock morbidity and mortality rates. By fostering a well-rounded, nutrient-rich
diet, transferrin ultimately supports optimal growth and robust health in
livestock.
Is transferrin safe to use in animal feeds, and are there any
potential side effects?
Transferrin is generally considered safe for use in animal
feeds and has been extensively studied for its efficacy and safety. It is a naturally
occurring protein that animals and humans produce endogenously, which mitigates the
risks associated with foreign substances. There have been very few reports of adverse
reactions when transferrin is used correctly and within recommended dosages. However,
excessive amounts of transferrin, like any nutrient, could potentially lead to
imbalances. For example, too much iron absorption might promote conditions such as
hemosiderosis, an excess storage of iron in organs, even though this is a rare
occurrence. As with any feed supplement, it is advisable to follow manufacturer
guidelines meticulously and consult with a veterinary nutritionist to ensure the correct
dosage and ratio in the diet.
Can transferrin be used in all types of livestock,
and does it require any special handling or storage conditions?
Transferrin can be
effectively used in a wide range of livestock, including poultry, swine, cattle, and
even aquatic species like fish. Its benefits are universal due to its fundamental role
in iron metabolism and immune support, although the specific dosage and formulation
might vary depending on the species and their nutritional requirements. As for handling,
transferrin should generally be stored in a cool, dry place away from direct sunlight to
preserve its stability and efficacy. It’s crucial to keep it in airtight containers to
protect it from moisture and contaminants. No special handling is typically required
beyond standard storage recommendations for feed additives. Ensuring proper storage
conditions will maintain the protein’s integrity and maximize its beneficial impacts on
livestock health and growth.