Synonym: Y04401
Species: Human
Protein Accession: P01375
Purity: ≥ 98%
Endotoxin Level:
< 0.1 EU per 1 μg of the protein
Biological Activity: The ED₅₀ of ≤ 0.05 ng/ml was determined by its
ability to inhibit the cytotoxicity of murine L929 cells in the presence of
actinomycin D.
Expression System: E. coli
Fusion Tag: None
Predicted Molecular Mass: Approximately 17.4 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,
350 mM NaCl, pH 7.5
Reconstitution: It is recommended to reconstitute the lyophilized TNFα in
sterile 18 MΩ-cm H₂O not less than 100 μg/ml, which can then be further diluted
to other aqueous solutions.
Storage & Stability: Store lyophilized protein at -20°C. Aliquot the
product after reconstitution to avoid repeated freeze-thaw cycles. Reconstituted
protein can be stored at 4°C for a limited period of time.
FAQ
What is Y04401 Recombinant Human TNFα, and how can it benefit the feed
industry?
Y04401 Recombinant Human TNFα (Tumor Necrosis Factor-alpha) is
a bioengineered version of the naturally occurring cytokine TNFα. This cytokine
plays a crucial role in immune system regulation and inflammatory response. In
the feed industry, Y04401 can be utilized to enhance the immune responses of
livestock, leading to improved resistance to infections and diseases. By
boosting the innate immunity of animals, the overall health and productivity of
livestock are increased. This results in better growth rates, feed efficiency,
and reduced use of antibiotics. Additionally, healthier livestock tends to have
higher meat and milk yields, contributing to more sustainable and profitable
farming practices.
How is Y04401 Recombinant Human TNFα administered to
livestock, and what are the recommended dosages?
Y04401 Recombinant Human
TNFα can be administered to livestock through various methods, including
injections, oral formulations, or adding it directly into feed or water. The
choice of administration depends on the specific needs and logistics of the farm
operation. Generally, the dosage should be tailored to the species, age, and
health status of the animals. Studies suggest starting with a low dose and
gradually increasing it while monitoring the animals for any adverse effects or
improvements in health. It is advisable to consult with a veterinarian or an
animal nutritionist to determine the most effective dosage and administration
route. This ensures that the application is both safe and beneficial for the
livestock.
What are the potential side effects or risks associated with
the use of Y04401 Recombinant Human TNFα in livestock?
While Y04401
Recombinant Human TNFα has shown promising benefits, it's important to be aware
of potential side effects. Overstimulation of the immune system can sometimes
lead to inflammation or autoimmune responses. Signs such as fever, reduced
appetite, or lethargy could indicate adverse reactions. Moreover, improper
dosages or prolonged use may lead to resistance or diminishing returns in
effectiveness. Therefore, monitoring the health and behavior of the livestock
closely after administration is crucial. Collaboration with veterinarians and
nutritionists can help in mitigating these risks and ensuring that the use of
Y04401 remains beneficial and safe.
How does Y04401 Recombinant Human
TNFα compare to traditional antibiotics and growth promoters in the feed
industry?
Y04401 Recombinant Human TNFα offers a biological approach to
enhancing livestock health, distinguishing it from traditional antibiotics and
chemical growth promoters. Unlike antibiotics, which can lead to resistance and
residue issues, TNFα works by enhancing the animal's own immune system. This
method reduces the need for antibiotics, aligning with global efforts to combat
antibiotic resistance. Additionally, while chemical growth promoters can have
various side effects and regulatory restrictions, TNFα is a naturally occurring
protein, which is generally perceived as safer and more acceptable. However,
it's essential to note that TNFα and traditional methods can be complementary
when used judiciously. The combination can offer a balanced approach to
maximizing livestock productivity and health.
Can Y04401 Recombinant
Human TNFα be used for all types of livestock, and are there specific
considerations for different species?
Y04401 Recombinant Human TNFα has
potential applications across various livestock species, including cattle,
swine, poultry, and fish. However, the response to TNFα can vary among species
due to differences in immune system functioning and physiology. For instance,
while cattle might show significant improvements in milk production and disease
resistance, poultry may benefit more from enhanced growth rates and reduced
mortality. Additionally, dosage and administration methods might differ; for
example, injectable forms might be more suitable for larger animals like cattle,
whereas oral administration can be more practical for poultry and swine.
Species-specific research and consultation with experts are crucial to optimize
the use of Y04401 for different types of livestock, ensuring that it meets the
unique needs of each species effectively.