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Y04401 Recombinant Human TNFα

Synonym: Y04401

Species: Human

Protein Accession: P01375

Purity: ≥ 98%

Endotoxin Level: < 0.1 EU per 1 μg of the protein

Biological Activity: The ED₅₀ of ≤ 0.05 ng/ml was determined by its ability to inhibit the cytotoxicity of murine L929 cells in the presence of actinomycin D.

Expression System: E. coli

Fusion Tag: None

Predicted Molecular Mass: Approximately 17.4 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 350 mM NaCl, pH 7.5

Reconstitution: It is recommended to reconstitute the lyophilized TNFα in sterile 18 MΩ-cm H₂O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.

Storage & Stability: Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freeze-thaw cycles. Reconstituted protein can be stored at 4°C for a limited period of time.

FAQ

What is Y04401 Recombinant Human TNFα, and how can it benefit the feed industry?

Y04401 Recombinant Human TNFα (Tumor Necrosis Factor-alpha) is a bioengineered version of the naturally occurring cytokine TNFα. This cytokine plays a crucial role in immune system regulation and inflammatory response. In the feed industry, Y04401 can be utilized to enhance the immune responses of livestock, leading to improved resistance to infections and diseases. By boosting the innate immunity of animals, the overall health and productivity of livestock are increased. This results in better growth rates, feed efficiency, and reduced use of antibiotics. Additionally, healthier livestock tends to have higher meat and milk yields, contributing to more sustainable and profitable farming practices.

How is Y04401 Recombinant Human TNFα administered to livestock, and what are the recommended dosages?

Y04401 Recombinant Human TNFα can be administered to livestock through various methods, including injections, oral formulations, or adding it directly into feed or water. The choice of administration depends on the specific needs and logistics of the farm operation. Generally, the dosage should be tailored to the species, age, and health status of the animals. Studies suggest starting with a low dose and gradually increasing it while monitoring the animals for any adverse effects or improvements in health. It is advisable to consult with a veterinarian or an animal nutritionist to determine the most effective dosage and administration route. This ensures that the application is both safe and beneficial for the livestock.

What are the potential side effects or risks associated with the use of Y04401 Recombinant Human TNFα in livestock?

While Y04401 Recombinant Human TNFα has shown promising benefits, it's important to be aware of potential side effects. Overstimulation of the immune system can sometimes lead to inflammation or autoimmune responses. Signs such as fever, reduced appetite, or lethargy could indicate adverse reactions. Moreover, improper dosages or prolonged use may lead to resistance or diminishing returns in effectiveness. Therefore, monitoring the health and behavior of the livestock closely after administration is crucial. Collaboration with veterinarians and nutritionists can help in mitigating these risks and ensuring that the use of Y04401 remains beneficial and safe.

How does Y04401 Recombinant Human TNFα compare to traditional antibiotics and growth promoters in the feed industry?

Y04401 Recombinant Human TNFα offers a biological approach to enhancing livestock health, distinguishing it from traditional antibiotics and chemical growth promoters. Unlike antibiotics, which can lead to resistance and residue issues, TNFα works by enhancing the animal's own immune system. This method reduces the need for antibiotics, aligning with global efforts to combat antibiotic resistance. Additionally, while chemical growth promoters can have various side effects and regulatory restrictions, TNFα is a naturally occurring protein, which is generally perceived as safer and more acceptable. However, it's essential to note that TNFα and traditional methods can be complementary when used judiciously. The combination can offer a balanced approach to maximizing livestock productivity and health.

Can Y04401 Recombinant Human TNFα be used for all types of livestock, and are there specific considerations for different species?

Y04401 Recombinant Human TNFα has potential applications across various livestock species, including cattle, swine, poultry, and fish. However, the response to TNFα can vary among species due to differences in immune system functioning and physiology. For instance, while cattle might show significant improvements in milk production and disease resistance, poultry may benefit more from enhanced growth rates and reduced mortality. Additionally, dosage and administration methods might differ; for example, injectable forms might be more suitable for larger animals like cattle, whereas oral administration can be more practical for poultry and swine. Species-specific research and consultation with experts are crucial to optimize the use of Y04401 for different types of livestock, ensuring that it meets the unique needs of each species effectively.

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