Synonym: PDGF-BB
Species: Human
Protein Accession: P01127
Purity: Greater than 95%
Endotoxin Level: Less than 0.1 ng/μg (1 EU/μg)
Biological Activity: The ED50 for this effect is typically between 2-10 ng/mL.
Expression System: E. coli
Fusion Tag: None
Predicted Molecular Mass: Approximately 24 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl,
pH 7.5
Reconstitution: Centrifuge the vial prior to opening. Reconstitute in sterile
distilled water to a concentration of 0.1-1.0 mg/mL.
Storage & Stability: Store lyophilized protein at -20°C. Aliquot reconstituted
protein and store at -20°C to -80°C. Avoid repeated freeze-thaw cycles.
FAQ
What is Y03401 Recombinant Human PDGF-BB, and how can it benefit the feed
industry?
Y03401 Recombinant Human PDGF-BB (Platelet-Derived Growth Factor-BB) is
a bioengineered protein that plays a crucial role in cell proliferation,
differentiation, and angiogenesis. In the feed industry, it can offer multiple benefits
by enhancing the overall growth and health of livestock. PDGF-BB has been shown to
accelerate tissue repair and regeneration, potentially improving recovery times and
overall vitality. Additionally, its role in cell differentiation can contribute to more
efficient growth and development in animals, resulting in better feed conversion rates
and potentially lower feed costs. Incorporating PDGF-BB into animal feed may also
enhance the immune system, resulting in healthier livestock resistant to diseases,
thereby reducing the need for antibiotics and other veterinary interventions.
How
does PDGF-BB promote growth and development in livestock?
PDGF-BB stimulates
cellular activities that are vital for growth and development, particularly in the
context of skeletal and muscular systems. It achieves this by binding to specific
receptors on the surface of target cells, triggering a cascade of cellular events that
lead to proliferation and differentiation. These actions can significantly accelerate
the repair of tissues and support the formation of new blood vessels, ensuring efficient
nutrient delivery to developing tissues. For young animals, this can mean faster and
more balanced growth, while for adults, it can aid in quicker recovery from injuries or
stress. The boost in overall cellular health and metabolic efficiency can translate to
better weight gain and improved feed conversion ratios, making PDGF-BB a valuable
additive in animal nutrition programs.
Is the use of recombinant proteins like
PDGF-BB safe for animals?
Yes, the use of recombinant proteins such as PDGF-BB is
generally safe for animals, provided they are produced under stringent quality controls
and go through rigorous testing. PDGF-BB is naturally present in the body and plays a
fundamental role in various physiological processes. When administered through feed, it
mimics these natural processes without introducing foreign substances or chemicals.
Recombinant PDGF-BB is produced through advanced biotechnological methods that ensure
its purity and bioactivity, reducing the risk of adverse reactions. However, it is
essential to follow recommended dosages and guidelines to prevent over-supplementation,
which can lead to unintended effects. Continuous monitoring and assessment can ensure
its long-term safety and efficacy in animal feed.
What are the potential economic
benefits of incorporating PDGF-BB into animal feed?
Incorporating PDGF-BB into
animal feed can offer several economic benefits. First, by promoting faster growth and
improving feed conversion rates, farmers can achieve market readiness more quickly,
reducing overall production cycles and associated costs. Healthier animals require fewer
veterinary interventions, including treatments and medications, which can significantly
decrease operational expenses. The enhanced immune response from PDGF-BB can lead to
lower mortality rates and reduced losses due to illnesses, thereby protecting the
farmer's investment. Additionally, improved tissue health and recovery times can
minimize downtime and ensure continuous productivity. The cumulative effect of these
benefits can result in higher profitability and a more sustainable farming
operation.
Are there any regulatory concerns regarding the use of PDGF-BB in
feed?
The use of PDGF-BB in feed is subject to regulatory oversight to ensure its
safety and efficacy. Regulatory bodies such as the U.S. Food and Drug Administration
(FDA) and the European Food Safety Authority (EFSA) have established guidelines for the
approval and use of feed additives. These guidelines include thorough evaluation of the
product's safety for animals, potential impact on human health, and environmental
considerations. Manufacturers must provide detailed documentation and scientific
evidence supporting the product's safety and benefits. Once approved, adherence to
regulatory standards and ongoing monitoring are essential to ensure compliance and
maintain trust within the industry. While regulatory processes can be stringent, they
ultimately ensure that the introduction of PDGF-BB into feed is both safe and beneficial
for all stakeholders involved.