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Y03401 Recombinant Human PDGF-BB

Synonym: PDGF-BB

Species: Human

Protein Accession: P01127

Purity: Greater than 95%

Endotoxin Level: Less than 0.1 ng/μg (1 EU/μg)

Biological Activity: The ED50 for this effect is typically between 2-10 ng/mL.

Expression System: E. coli

Fusion Tag: None

Predicted Molecular Mass: Approximately 24 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.5

Reconstitution: Centrifuge the vial prior to opening. Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.

Storage & Stability: Store lyophilized protein at -20°C. Aliquot reconstituted protein and store at -20°C to -80°C. Avoid repeated freeze-thaw cycles.

FAQ

What is Y03401 Recombinant Human PDGF-BB, and how can it benefit the feed industry?

Y03401 Recombinant Human PDGF-BB (Platelet-Derived Growth Factor-BB) is a bioengineered protein that plays a crucial role in cell proliferation, differentiation, and angiogenesis. In the feed industry, it can offer multiple benefits by enhancing the overall growth and health of livestock. PDGF-BB has been shown to accelerate tissue repair and regeneration, potentially improving recovery times and overall vitality. Additionally, its role in cell differentiation can contribute to more efficient growth and development in animals, resulting in better feed conversion rates and potentially lower feed costs. Incorporating PDGF-BB into animal feed may also enhance the immune system, resulting in healthier livestock resistant to diseases, thereby reducing the need for antibiotics and other veterinary interventions.

How does PDGF-BB promote growth and development in livestock?

PDGF-BB stimulates cellular activities that are vital for growth and development, particularly in the context of skeletal and muscular systems. It achieves this by binding to specific receptors on the surface of target cells, triggering a cascade of cellular events that lead to proliferation and differentiation. These actions can significantly accelerate the repair of tissues and support the formation of new blood vessels, ensuring efficient nutrient delivery to developing tissues. For young animals, this can mean faster and more balanced growth, while for adults, it can aid in quicker recovery from injuries or stress. The boost in overall cellular health and metabolic efficiency can translate to better weight gain and improved feed conversion ratios, making PDGF-BB a valuable additive in animal nutrition programs.

Is the use of recombinant proteins like PDGF-BB safe for animals?

Yes, the use of recombinant proteins such as PDGF-BB is generally safe for animals, provided they are produced under stringent quality controls and go through rigorous testing. PDGF-BB is naturally present in the body and plays a fundamental role in various physiological processes. When administered through feed, it mimics these natural processes without introducing foreign substances or chemicals. Recombinant PDGF-BB is produced through advanced biotechnological methods that ensure its purity and bioactivity, reducing the risk of adverse reactions. However, it is essential to follow recommended dosages and guidelines to prevent over-supplementation, which can lead to unintended effects. Continuous monitoring and assessment can ensure its long-term safety and efficacy in animal feed.

What are the potential economic benefits of incorporating PDGF-BB into animal feed?

Incorporating PDGF-BB into animal feed can offer several economic benefits. First, by promoting faster growth and improving feed conversion rates, farmers can achieve market readiness more quickly, reducing overall production cycles and associated costs. Healthier animals require fewer veterinary interventions, including treatments and medications, which can significantly decrease operational expenses. The enhanced immune response from PDGF-BB can lead to lower mortality rates and reduced losses due to illnesses, thereby protecting the farmer's investment. Additionally, improved tissue health and recovery times can minimize downtime and ensure continuous productivity. The cumulative effect of these benefits can result in higher profitability and a more sustainable farming operation.

Are there any regulatory concerns regarding the use of PDGF-BB in feed?

The use of PDGF-BB in feed is subject to regulatory oversight to ensure its safety and efficacy. Regulatory bodies such as the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA) have established guidelines for the approval and use of feed additives. These guidelines include thorough evaluation of the product's safety for animals, potential impact on human health, and environmental considerations. Manufacturers must provide detailed documentation and scientific evidence supporting the product's safety and benefits. Once approved, adherence to regulatory standards and ongoing monitoring are essential to ensure compliance and maintain trust within the industry. While regulatory processes can be stringent, they ultimately ensure that the introduction of PDGF-BB into feed is both safe and beneficial for all stakeholders involved.

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