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Y03001 Recombinant Human LIF

Synonym: LIF

Species: Human

Protein Accession: P15018

Purity: Greater than 98% as determined by SDS-PAGE

Endotoxin Level: Less than 0.1 ng/ug (1EU/ug)

Biological Activity: The ED50 for this effect is typically 0.2-1.0 ng/mL.

Expression System: E. coli

Fusion Tag: None

Predicted Molecular Mass: Approximately 20.8 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4

Reconstitution: It is recommended to reconstitute the lyophilized Human LIF in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Storage & Stability: Store lyophilized product at -20°C. Reconstitution can be stored at 4°C for up to 2 weeks. For long term storage, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles.

FAQ

What is Y03001 Recombinant Human LIF and how is it beneficial for the feed industry?

Y03001 Recombinant Human Leukemia Inhibitory Factor (LIF) is a cytokine belonging to the interleukin-6 family, known for its multifaceted biological activities, including cell differentiation, proliferation, and survival. In the context of the feed industry, LIF can be particularly beneficial due to its ability to enhance growth rates, improve immune response, and increase overall health in livestock. This cytokine helps in optimizing feed efficiency, thereby reducing the cost of production and improving the economic value of livestock farming. By promoting a healthier and more robust immune system, animals can better resist infections and diseases, leading to reduced use of antibiotics and other medications, which is crucial for maintaining food safety standards. Additionally, LIF's role in cellular health and development can result in better meat quality and yield, providing a competitive edge in the marketplace.

How does Y03001 Recombinant Human LIF improve the immune response in livestock?

LIF plays a critical role in modulating the immune system by influencing the activity of various immune cells. It enhances the production and function of leukocytes, particularly macrophages and lymphocytes, which are essential for a robust immune response. By stimulating these cells, LIF improves the animal's ability to fend off pathogens and recover from infections more swiftly. This is particularly valuable in intensive farming environments where animals are in close quarters and more susceptible to diseases. LIF also has anti-inflammatory properties that help in reducing the overall inflammatory load on the animal, promoting quicker recovery and maintaining overall health. The use of LIF in feed can, therefore, reduce veterinary costs and minimize the loss associated with disease outbreaks, contributing to more sustainable livestock management.

In what ways can Y03001 Recombinant Human LIF enhance growth rates in livestock?

LIF impacts growth by influencing various cellular pathways that regulate cell proliferation, differentiation, and metabolism. When included in feed, LIF can enhance the growth hormone signaling pathways and increase the expression of genes involved in muscle development and fat metabolism. This results in not only faster growth rates but also an improved feed conversion ratio (FCR), meaning animals require less feed to gain the same amount of weight. Improved growth rates also translate to shorter time to market, optimizing production cycles and increasing potential revenue. The integration of LIF in animal feed ensures that the livestock grow healthier and stronger, presenting a dual benefit of increased productivity and enhanced animal welfare.

What are the potential safety concerns associated with Y03001 Recombinant Human LIF in animal feed?

The safety of Y03001 Recombinant Human LIF in animal feed is a primary consideration, and comprehensive studies must be conducted to ensure its non-toxicity and efficacy. Generally, recombinant proteins like LIF are produced using biotechnological methods that ensure high purity and minimal contaminants. It's crucial to adhere to regulatory guidelines and conduct rigorous trials to assess any adverse effects. Given its high homology with naturally occurring LIF, the risk of negative reactions is relatively low. However, continuous monitoring and assessment will ensure safe and effective integration into feed protocols. Proper dosing and administration guidelines should be followed to avoid potential issues like overstimulation of the immune system, which could lead to autoimmune responses or other imbalances.

Can the application of Y03001 Recombinant Human LIF replace antibiotics in livestock production?

Y03001 Recombinant Human LIF holds potential as a natural alternative to antibiotics by bolstering the immune system and improving overall health, thereby reducing the necessity for antibiotic interventions. Its role in enhancing the animal's natural defenses means that livestock can more effectively fight off infections, mitigating the spread of diseases. This is particularly important given the global push to reduce antibiotic use to combat antimicrobial resistance (AMR). While LIF may not entirely replace the need for antibiotics, its inclusion in feed can significantly reduce dependency on them, promoting a more sustainable and responsible approach to livestock management. It is crucial to adopt a holistic view, considering LIF as part of an integrated disease management strategy, including good farm hygiene, regular health monitoring, and proper nutrition.

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