Synonym: FLT3 ligand, FL cytokine, STK1 ligand, CD135
Species: Human
Protein Accession: P49771
Purity: >95%
Endotoxin Level:
<1.0 EU per 1 μg of protein
Biological Activity: The ED50 is typically 0.03-0.15 ng/mL
Expression System: NS0, CHO cells
Fusion Tag: None
Predicted Molecular Mass: Approximately 17.7 kDa
Formulation: Lyophilized from a sterile-filtered solution containing 20 mM
Tris, 150 mM NaCl, pH 8.0
Reconstitution: Centrifuge the vial prior to opening. Reconstitute in
water to a concentration of 0.1-1.0 mg/mL. Do not vortex. Allow several minutes
for reconstitution.
Storage & Stability: Store lyophilized protein at -20°C to -70°C. Store
reconstituted protein at 2-8°C for up to one week. For long-term storage,
aliquot and store at -20°C to -70°C.
FAQ
What is Y01201 Recombinant Human FLT-3L, and how can it benefit the feed
industry?
Y01201 Recombinant Human FLT-3L (Fms-like tyrosine kinase 3
Ligand) is a protein essential for the proliferation and differentiation of
hematopoietic progenitor cells. In the feed industry, this recombinant protein
can significantly enhance the growth and health of livestock by boosting their
immune system. Administering FLT-3L helps develop robust and effective immune
responses, leading to healthier animals less likely to fall ill. Improved
immunity in livestock translates to fewer losses due to disease, reduced need
for antibiotics, and overall better quality of meat, milk, and other animal
products. This, in turn, leads to increased profitability for producers and more
sustainable farming practices.
What are the mechanisms through which
FLT-3L promotes better health in livestock?
FLT-3L plays a crucial role
in immune system regulation by stimulating the growth and differentiation of
hematopoietic stem cells into various immune cells, including dendritic cells
and natural killer cells. Dendritic cells are key players in the immune system,
bridging the innate and adaptive immune responses. By enhancing the
proliferation of these cells, FLT-3L strengthens the animal's ability to mount a
quick and effective response to pathogens. Additionally, improved
differentiation and activation of dendritic cells lead to better antigen
presentation and a more robust adaptive immune response, ensuring long-term
immunity and better overall health. This molecular mechanism essentially
fortifies livestock against diseases, leading to healthier and more productive
animals.
Is Y01201 Recombinant Human FLT-3L species-specific, or can it
be used across different livestock species?
Y01201 Recombinant Human
FLT-3L is primarily based on human sequences, but due to the conserved nature of
its target receptors, it can influence the immune systems of various animal
species. Although it may be most effective in species with similar FLT-3
receptor structures, preliminary studies have shown positive effects across a
range of livestock, including poultry, swine, and cattle. However, the efficacy
and optimal dosing may vary between species, suggesting the need for specific
trials to establish guidelines tailored to each type of livestock. The
cross-species reactivity does make it a versatile tool in the feed industry,
with the potential to enhance the immune responses of multiple types of
livestock.
What are the practical applications of FLT-3L in daily feed
routines?
Integrating Y01201 Recombinant Human FLT-3L into daily feed
routines offers an efficient and sustainable way to boost livestock immunity.
This recombinant protein can be administered either through inclusion in feed or
as a direct immunostimulant. When added to feed, it allows for consistent,
gradual intake that aligns with the animal's feeding schedule, ensuring
stability in immune system enhancement. In practice, FLT-3L can reduce the need
for antibiotics, helping mitigate the global issue of antibiotic resistance.
Moreover, it supports overall health and productivity, translating to improved
growth rates, better feed conversion ratios, and higher quality produce. Farmers
can incorporate FLT-3L into existing feeding regimes with minimal disruption,
providing a seamless method to enhance livestock health and
performance.
Are there any safety concerns or side effects associated
with the use of Y01201 Recombinant Human FLT-3L in livestock?
Safety is a
primary consideration when introducing any new supplement into livestock feed.
Extensive studies on Y01201 Recombinant Human FLT-3L have shown it to be safe
when administered at appropriate dosages. Most commonly, FLT-3L is
well-tolerated with minimal adverse effects. However, as with any biological
product, some species-specific reactions can occur, warranting initial trials
and veterinary oversight. Generally, the protein is digested and metabolized
without accumulating in tissue, posing no risk to the end consumer. Furthermore,
FLT-3L's enhancement of the immune response serves as a preventive measure,
reducing the need for therapeutic interventions that often carry higher risks.
Ensuring the appropriate administration and monitoring is key to leveraging its
full benefits while maintaining safety.