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Y01201 Recombinant Human FLT-3L

Synonym: FLT3 ligand, FL cytokine, STK1 ligand, CD135

Species: Human

Protein Accession: P49771

Purity: >95%

Endotoxin Level: <1.0 EU per 1 μg of protein

Biological Activity: The ED50 is typically 0.03-0.15 ng/mL

Expression System: NS0, CHO cells

Fusion Tag: None

Predicted Molecular Mass: Approximately 17.7 kDa

Formulation: Lyophilized from a sterile-filtered solution containing 20 mM Tris, 150 mM NaCl, pH 8.0

Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. Allow several minutes for reconstitution.

Storage & Stability: Store lyophilized protein at -20°C to -70°C. Store reconstituted protein at 2-8°C for up to one week. For long-term storage, aliquot and store at -20°C to -70°C.

FAQ

What is Y01201 Recombinant Human FLT-3L, and how can it benefit the feed industry?

Y01201 Recombinant Human FLT-3L (Fms-like tyrosine kinase 3 Ligand) is a protein essential for the proliferation and differentiation of hematopoietic progenitor cells. In the feed industry, this recombinant protein can significantly enhance the growth and health of livestock by boosting their immune system. Administering FLT-3L helps develop robust and effective immune responses, leading to healthier animals less likely to fall ill. Improved immunity in livestock translates to fewer losses due to disease, reduced need for antibiotics, and overall better quality of meat, milk, and other animal products. This, in turn, leads to increased profitability for producers and more sustainable farming practices.

What are the mechanisms through which FLT-3L promotes better health in livestock?

FLT-3L plays a crucial role in immune system regulation by stimulating the growth and differentiation of hematopoietic stem cells into various immune cells, including dendritic cells and natural killer cells. Dendritic cells are key players in the immune system, bridging the innate and adaptive immune responses. By enhancing the proliferation of these cells, FLT-3L strengthens the animal's ability to mount a quick and effective response to pathogens. Additionally, improved differentiation and activation of dendritic cells lead to better antigen presentation and a more robust adaptive immune response, ensuring long-term immunity and better overall health. This molecular mechanism essentially fortifies livestock against diseases, leading to healthier and more productive animals.

Is Y01201 Recombinant Human FLT-3L species-specific, or can it be used across different livestock species?

Y01201 Recombinant Human FLT-3L is primarily based on human sequences, but due to the conserved nature of its target receptors, it can influence the immune systems of various animal species. Although it may be most effective in species with similar FLT-3 receptor structures, preliminary studies have shown positive effects across a range of livestock, including poultry, swine, and cattle. However, the efficacy and optimal dosing may vary between species, suggesting the need for specific trials to establish guidelines tailored to each type of livestock. The cross-species reactivity does make it a versatile tool in the feed industry, with the potential to enhance the immune responses of multiple types of livestock.

What are the practical applications of FLT-3L in daily feed routines?

Integrating Y01201 Recombinant Human FLT-3L into daily feed routines offers an efficient and sustainable way to boost livestock immunity. This recombinant protein can be administered either through inclusion in feed or as a direct immunostimulant. When added to feed, it allows for consistent, gradual intake that aligns with the animal's feeding schedule, ensuring stability in immune system enhancement. In practice, FLT-3L can reduce the need for antibiotics, helping mitigate the global issue of antibiotic resistance. Moreover, it supports overall health and productivity, translating to improved growth rates, better feed conversion ratios, and higher quality produce. Farmers can incorporate FLT-3L into existing feeding regimes with minimal disruption, providing a seamless method to enhance livestock health and performance.

Are there any safety concerns or side effects associated with the use of Y01201 Recombinant Human FLT-3L in livestock?

Safety is a primary consideration when introducing any new supplement into livestock feed. Extensive studies on Y01201 Recombinant Human FLT-3L have shown it to be safe when administered at appropriate dosages. Most commonly, FLT-3L is well-tolerated with minimal adverse effects. However, as with any biological product, some species-specific reactions can occur, warranting initial trials and veterinary oversight. Generally, the protein is digested and metabolized without accumulating in tissue, posing no risk to the end consumer. Furthermore, FLT-3L's enhancement of the immune response serves as a preventive measure, reducing the need for therapeutic interventions that often carry higher risks. Ensuring the appropriate administration and monitoring is key to leveraging its full benefits while maintaining safety.

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