Synonym: IL-12, NKSF, Cytotoxic lymphocyte maturation factor 2 (CLMF2), p70
Species: Human
Protein Accession: P29460
Purity: ≥95%
Endotoxin Level:
<0.1 ng per µg of protein
Biological Activity: Fully biologically active when compared to standard.
The ED50 as determined by a cell proliferation assay using human NK cells is
less than 0.5 ng/ml, corresponding to a specific activity of >2.0x106 IU/mg.
Expression System: HEK 293 cells
Fusion Tag: None
Predicted Molecular Mass: 21.5 kDa
Formulation: Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM
NaCl, pH7.0
Reconstitution: It is recommended to reconstitute the lyophilized
recombinant Human IL-12 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can
then be further diluted to other aqueous solutions.
Storage & Stability: Store lyophilized recombinant Human IL-12 at -20°C.
It is stable for up to 12 months from date of receipt when stored at -20°C to
-80°C. Reconstituted IL-12 should be stored in working aliquots at -20°C.
FAQ
What is Y04001 Recombinant Human IL-12 and how does it benefit the feed
industry?
Y04001 Recombinant Human IL-12 is a synthetic form of the
naturally occurring interleukin-12 (IL-12) protein. IL-12 is a cytokine that
plays a significant role in the immune response by enhancing the functionality
of T-cells and natural killer (NK) cells. In the feed industry, utilizing Y04001
Recombinant Human IL-12 can markedly improve animal health and productivity. Its
immune-boosting properties can help in reducing the prevalence of diseases,
thereby minimizing the need for antibiotics. This approach supports the trend
towards antibiotic-free meat production, meeting consumer demand for safer and
more natural animal products. Additionally, healthier animals tend to exhibit
better growth rates and feed conversion efficiency, resulting in economic
benefits for farmers and producers.
How is Y04001 Recombinant Human IL-12
administered to animals in the feed industry?
Y04001 Recombinant Human
IL-12 can be administered in several ways to ensure its effectiveness and ease
of use within the feed industry. One common method is incorporation into feed or
water, allowing for easy mass administration without the need for individual
handling. This method ensures that all animals receive the cytokine
consistently, enhancing overall herd health. Alternatively, it can be
administered via injectable formulations for targeted therapy in high-risk
scenarios or to individual animals that require immediate immune support.
Adapting the mode of administration to the specific needs of the production
system can optimize the benefits of Y04001 Recombinant Human IL-12, making it a
versatile tool for enhancing animal welfare and production
efficiency.
Are there any safety concerns associated with the use of
Y04001 Recombinant Human IL-12 in animal feed?
The use of Y04001
Recombinant Human IL-12 in animal feed is generally considered safe, provided it
is used according to recommended guidelines and dosages. Extensive research and
testing are conducted to ensure that recombinant cytokines like IL-12 do not
pose toxicity risks to animals or humans who might consume the animal products.
Regulatory agencies evaluate these products rigorously before approval for use
in the feed industry. Potential side effects are usually minimal and may include
temporary changes in animal behavior or mild inflammatory responses, which are
often indicative of the immune system activation desired by the product. Routine
monitoring and adherence to recommended usage protocols can mitigate most safety
concerns, ensuring that the benefits of IL-12 are harnessed
effectively.
Can Y04001 Recombinant Human IL-12 be used in combination
with other feed additives or medications?
Yes, Y04001 Recombinant Human
IL-12 can be used in combination with other feed additives or medications. Its
primary role is to enhance the animal's immune response, making it complementary
to other health and nutrition interventions rather than conflicting with them.
When used alongside probiotics, vitamins, and essential minerals, it can provide
a comprehensive approach to animal health. Additionally, Y04001 Recombinant
Human IL-12 can reduce reliance on antibiotics by boosting natural immunity,
promoting a healthier gut microbiome when combined with prebiotics or
probiotics. However, it is crucial to consult with a veterinarian or animal
nutritionist to ensure optimal combinations and dosing schedules that maximize
the effectiveness and safety of the feed regimen.
How does Y04001
Recombinant Human IL-12 improve animal welfare and productivity?
Y04001
Recombinant Human IL-12 significantly enhances animal welfare and productivity
by strengthening their immune systems, which leads to reduced incidence of
diseases and infections. As animals become less susceptible to illnesses, there
is a marked improvement in their overall health and well-being. This leads to a
decrease in mortality rates and less need for medical interventions, which can
be stressful for animals. Healthier animals exhibit better growth rates and feed
conversion ratios, directly translating to increased productivity. Improved
immune function also means animals are better equipped to handle stress,
environmental changes, and other potential challenges in their living
conditions. This comprehensive boost in health and welfare not only aligns with
ethical farming practices but also supports economic gains through improved
product quality and quantity.