Synonym: IL-18
Species: Human
Protein Accession: P29460
Purity: >= 95%
Endotoxin Level:
< 0.1 EU per 1 μg of the protein
Biological Activity: Fully biologically active when compared to standard.
Expression System: E. coli
Fusion Tag: None
Predicted Molecular Mass: 18.1 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4
Reconstitution: It is recommended to reconstitute the lyophilized IL-18 in
sterile 18 MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted
to other aqueous solutions.
Storage & Stability: Store at -20°C upon receiving and at -80°C for longer
term. For extended storage, it is recommended to store at -20°C or -80°C in
appropriate aliquots.
FAQ
What is Y02801 Recombinant Human IL-18 and how does it benefit the feed
industry?
Y02801 Recombinant Human IL-18 (rhIL-18) is a manufactured
protein that mimics the naturally occurring Interleukin-18 in the human body. In
the feed industry, this cytokine holds substantial promise due to its
immunomodulatory properties. When incorporated into feed formulations, rhIL-18
can help enhance the immune response in livestock and poultry, making them more
resistant to infectious diseases. Animals with a stronger immune system often
have reduced dependency on antibiotics and other medications, leading to
healthier, more productive livestock. Moreover, this can translate to lower
mortality rates, faster growth rates, and improved feed conversion ratios, which
are vital metrics for efficiency in the feed industry. By promoting better
immunity, rhIL-18 also contributes to the welfare of the animals, making it a
valuable addition to modern feed products.
How is Y02801 Recombinant
Human IL-18 administered to livestock and poultry?
Y02801 Recombinant
Human IL-18 is typically administered through feed incorporation. The feed is
formulated such that an optimal dose of rhIL-18 is mixed uniformly throughout,
ensuring consistent intake by all animals. This method allows for easy, scalable
administration without the need for individual dosing. The formulation process
is carefully controlled to maintain the stability and activity of rhIL-18
throughout the feed manufacturing and storage processes. It’s crucial to follow
the manufacturer’s guidelines regarding dosage and mixing techniques to ensure
the effectiveness of the cytokine. Alternatively, it may also be administered
via water-soluble forms in drinking water, providing flexibility in how it’s
delivered according to the farm's setup and specific needs.
What impact
does Y02801 Recombinant Human IL-18 have on animal health?
Administering
Y02801 Recombinant Human IL-18 significantly impacts animal health by enhancing
the immune system’s ability to combat pathogens. rhIL-18 stimulates the
production of interferon-gamma (IFN-γ) and other cytokines, which are critical
for immune system activation. By boosting these immune responses, animals are
better equipped to fend off infections, leading to fewer outbreaks and less
severe disease symptoms. This means healthier livestock that exhibit better
overall productivity and growth. Furthermore, a robust immune system reduces the
need for antibiotic treatments, aligning with the growing demand for
antibiotic-free animal products. Healthier animals also show improved welfare
and reduced stress levels, which are essential factors for sustainable and
ethical livestock farming.
Are there any known side effects or risks
associated with using Y02801 Recombinant Human IL-18 in animal feed?
As
with any bioactive compound, it’s essential to use Y02801 Recombinant Human
IL-18 within the recommended dosages to minimize any potential side effects or
risks. Current studies indicate that when administered correctly, rhIL-18 is
generally safe and well-tolerated by livestock. However, excessive doses might
potentially lead to an overactive immune response, which could cause chronic
inflammation or other immune-related issues. It’s crucial to adhere strictly to
the guidelines provided by the manufacturer and monitor animals routinely for
any adverse reactions. Working closely with veterinary professionals can help
manage and mitigate risks, ensuring the health benefits of rhIL-18 are maximized
while maintaining animal welfare and safety.
Can Y02801 Recombinant Human
IL-18 be used in all types of livestock and poultry?
Y02801 Recombinant
Human IL-18 has shown promising results across a range of livestock and poultry
species, including chickens, turkeys, pigs, and cattle. Each species may respond
differently due to their unique immune system variances, and therefore, dosage
and administration methods may need to be adjusted accordingly. The benefits of
enhanced immune responses and improved disease resistance are generally
applicable across these different types of animals. Nevertheless, it’s important
to conduct specific trials within each species to optimize the use of rhIL-18
and tailor it to their unique needs. These trials help ensure that the
cytokine's benefits are harnessed effectively while avoiding any
species-specific adverse effects.