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Y02801 Recombinant Human IL-18

Synonym: IL-18

Species: Human

Protein Accession: P29460

Purity: >= 95%

Endotoxin Level: < 0.1 EU per 1 μg of the protein

Biological Activity: Fully biologically active when compared to standard.

Expression System: E. coli

Fusion Tag: None

Predicted Molecular Mass: 18.1 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4

Reconstitution: It is recommended to reconstitute the lyophilized IL-18 in sterile 18 MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.

Storage & Stability: Store at -20°C upon receiving and at -80°C for longer term. For extended storage, it is recommended to store at -20°C or -80°C in appropriate aliquots.

FAQ

What is Y02801 Recombinant Human IL-18 and how does it benefit the feed industry?

Y02801 Recombinant Human IL-18 (rhIL-18) is a manufactured protein that mimics the naturally occurring Interleukin-18 in the human body. In the feed industry, this cytokine holds substantial promise due to its immunomodulatory properties. When incorporated into feed formulations, rhIL-18 can help enhance the immune response in livestock and poultry, making them more resistant to infectious diseases. Animals with a stronger immune system often have reduced dependency on antibiotics and other medications, leading to healthier, more productive livestock. Moreover, this can translate to lower mortality rates, faster growth rates, and improved feed conversion ratios, which are vital metrics for efficiency in the feed industry. By promoting better immunity, rhIL-18 also contributes to the welfare of the animals, making it a valuable addition to modern feed products.

How is Y02801 Recombinant Human IL-18 administered to livestock and poultry?

Y02801 Recombinant Human IL-18 is typically administered through feed incorporation. The feed is formulated such that an optimal dose of rhIL-18 is mixed uniformly throughout, ensuring consistent intake by all animals. This method allows for easy, scalable administration without the need for individual dosing. The formulation process is carefully controlled to maintain the stability and activity of rhIL-18 throughout the feed manufacturing and storage processes. It’s crucial to follow the manufacturer’s guidelines regarding dosage and mixing techniques to ensure the effectiveness of the cytokine. Alternatively, it may also be administered via water-soluble forms in drinking water, providing flexibility in how it’s delivered according to the farm's setup and specific needs.

What impact does Y02801 Recombinant Human IL-18 have on animal health?

Administering Y02801 Recombinant Human IL-18 significantly impacts animal health by enhancing the immune system’s ability to combat pathogens. rhIL-18 stimulates the production of interferon-gamma (IFN-γ) and other cytokines, which are critical for immune system activation. By boosting these immune responses, animals are better equipped to fend off infections, leading to fewer outbreaks and less severe disease symptoms. This means healthier livestock that exhibit better overall productivity and growth. Furthermore, a robust immune system reduces the need for antibiotic treatments, aligning with the growing demand for antibiotic-free animal products. Healthier animals also show improved welfare and reduced stress levels, which are essential factors for sustainable and ethical livestock farming.

Are there any known side effects or risks associated with using Y02801 Recombinant Human IL-18 in animal feed?

As with any bioactive compound, it’s essential to use Y02801 Recombinant Human IL-18 within the recommended dosages to minimize any potential side effects or risks. Current studies indicate that when administered correctly, rhIL-18 is generally safe and well-tolerated by livestock. However, excessive doses might potentially lead to an overactive immune response, which could cause chronic inflammation or other immune-related issues. It’s crucial to adhere strictly to the guidelines provided by the manufacturer and monitor animals routinely for any adverse reactions. Working closely with veterinary professionals can help manage and mitigate risks, ensuring the health benefits of rhIL-18 are maximized while maintaining animal welfare and safety.

Can Y02801 Recombinant Human IL-18 be used in all types of livestock and poultry?

Y02801 Recombinant Human IL-18 has shown promising results across a range of livestock and poultry species, including chickens, turkeys, pigs, and cattle. Each species may respond differently due to their unique immune system variances, and therefore, dosage and administration methods may need to be adjusted accordingly. The benefits of enhanced immune responses and improved disease resistance are generally applicable across these different types of animals. Nevertheless, it’s important to conduct specific trials within each species to optimize the use of rhIL-18 and tailor it to their unique needs. These trials help ensure that the cytokine's benefits are harnessed effectively while avoiding any species-specific adverse effects.

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